These are extensively expressed inbrain cells (>1% of the total protein), and they mediate cellularCa2+ to control neuronal plasticity and cognitive functions.164 Inhibition of CaMKII has traditionally beena used as a therapeutic strategy for the treatment of heart diseases.165 However, CaMKII inhibitors have very recentlybeen proposed to inhibit flavivirus infections such as DENV and ZIKV.166 On the basis of previous investigations, aseries of benzenesulfonamides were designed and prepared to carryout a SAR study. Here, CAMK2G is linked to heart disorder.