The association of EPSTI1 with tumor metastatic potential is supported by observations that EPSTI1 is highly upregulated in invasive breast cancer tissues and suggested the role of EPSTI1 in promoting metastasis, tumorsphere formation, and stemness (Nielsen et al., 2002; Li et al., 2014; de Neergaard et al., 2010). Here, EPSTI1 is linked to breast cancer.