GSK3B and osteosarcoma: Compared with normal human osteoblast cells (hFOB1.19), the human osteosarcoma cells (MG63, SaOS-2, and U2-OS) showed higher protein expression levels of GSK3β and active form of GSK3β (p-GSK3βTyr216), while lower levels of inactive form of GSK3β (p-GSK3βSer9) (Figure 2).