Endothelin-1 is known to induce vasoconstriction followed by gradual reperfusion, recapitulating cerebrovascular dynamic post stroke in patients.45 ET-1 interacts with Endothelin-1A receptors, which are expressed preferentially in the arteriolar walls in the rat brain.46, –48 Accordingly, we observed a vasoconstricting effect of ET-1 in arterioles, but not in venules (Figure 1(b)): the changes in on venular VRBC were thus secondary to arteriolar VRBC changes. Here, EDN1 is linked to stroke disorder.