EDN1 and ischemia: Linear Mixed Effects model revealed that on average, VRBC of proximal arterioles decreased by 54 ± 4%, from 6.0 ± 2.2 mm/s at “baseline” to 2.6 ± 1.8 mm/sec during “ischemia” (p = 0.002), and then during “partial vRBC recovery,” which started 45 ± 13minutes following ET-1 injection (Supplementary Table 2), VRBC increased to 4.1 ± 2.2 mm/sec, thus rising by 58 ± 8% from its level during ischemia (p = 0.03).