WNT5A and melanoma: However, what has been shown is that WNT5A promotes epithelial‐to‐mesenchymal transition of melanoma cells [10] and that it triggers an increase in matrix metalloprotease (MMP) activity and a decrease E‐cadherin expression in epithelial carcinoma [22], implicating a potential role of the WNT5A ligand in tumor cell plasticity.