In these systems, depletion of colon macrophages or blockage of macrophage migration in response to C-C motif chemokine ligand 2 (CCL2) effectively inhibits microbiota-driven intestinal inflammation and reduces or abolishes tumor formation (Gu et al., 2019; Popivanova et al., 2009; Slowicka et al., 2020; Watanabe et al., 2003; Yang et al., 2013). The gene discussed is CCL2; the disease is neoplasm.