MIBE has been primarily investigated using E. faecalis as a pathobiont in the colitis-associated Il10 knockout (Il10−/−) murine model of CRC (Kim et al., 2005; Wang et al., 2008, 2015, 2012; Wang and Huycke, 2007; Yang et al., 2013, 2012). The gene discussed is IL10; the disease is colitis.