ADAR and Aicardi-Goutières syndrome: In Aicardi-Goutières Syndrome, loss of ADAR function results in accumulation of endogenous dsRNAs, activation of dsRNA sensors, and induction of IFNI/III, ISGs, additional inflammatory mediators and death in both murine models and human syndromes (Chen and Yang, 2017; Eisenberg and Levanon, 2018; Pfaller et al., 2018; Samuel, 2019; Yang et al., 2014).