More interestingly, while statin users have increased risk of AD (z‐value = 3.76, OR 2.00 [2.5% 1.4 to 97.5% 2.88], P = .00017), APOE ε4 carriers, reported to be using statins, appear to have a decreased risk for AD (z‐value = –1.77, OR 0.69 [2.5% 0.46 to 97.5% 1.04], P = .07), though non‐significant in our analysis. The gene discussed is APOE; the disease is Alzheimer disease.