To examine potential effects of statin on AD prevalence, a multivariate logistic regression model including statin use, APOE genotype, and sex as interaction terms found that APOE ε4 carriers demonstrate increased risk for AD (z‐value = 11.05, OR 4.88 [2.5% 3.68 to 97.5% 6.46], P < .0001). Here, APOE is linked to Alzheimer disease.