Further, while again statin‐using APOE ε4 carriers showed a non‐significant decreased risk for dementia (z‐value = –1.74, OR 0.78 [2.5% 0.58 to 97.5% 1.03], P = .08), males showed an increased risk for dementia (z‐value = 6.34, OR 1.84 [2.5% 1.52 to 97.5% 2.22], P < .0001), while males with an APOE ε4 genotype show a significant reduced risk for dementia (z‐value = –2.952, OR 0.66 [2.5% 0.5 to 97.5% 0.87], P = .003). The gene discussed is APOE; the disease is dementia.