Results from our study showed that hsa_circ_0058097, as the hub node in the ceRNA network, might contribute to GC progression and prognosis by the regulatory axes, such as hsa_circ_0058097/hsa_miR_145-5p/SERPINE1, hsa_circ_0058097/hsa_miR_133a-3p/COL1A1, hsa_circ_0058097/hsa_miR_133b/COL1A1, and hsa_circ_0058097/hsa_miR_1-3p/DKK1. This evidence concerns the gene COL1A1 and gastric cancer.