In addition, Yu et al. found that hsa_circ_0001445 could promote the expression of TIMP3, a well-known tumor suppressor, by sponging miR-17-3p and miR-181b-5p and further showed that hsa_circ_0001445 inhibits the growth and migration of hepatocellular carcinoma cells in vitro and in vivo data, providing a fresh perspective on circRNAs in hepatocellular carcinoma progression [19]. The gene discussed is TIMP3; the disease is hepatocellular carcinoma.