We found that hsa_circ_0058097 regulated multiple carcinogenic and prognosis-related genes, which might contribute to GC progression and prognosis by the regulatory axes, such as hsa_circ_0058097/hsa_miR_145-5p/SERPINE1, hsa_circ_0058097/hsa_miR_133a-3p/COL1A1, and hsa_circ_0058097/hsa_miR_1-3p/MET. This evidence concerns the gene SERPINE1 and gastric cancer.