Considering the abovementioned papers, despite the lack of a consensus, TCL is likely to be correctly diagnosed if a lymph node presents with cytology/histology suggestive of lymphoma and if (1) a prevalent population of medium-to-large lymphoid cells (≥1.3 times the size of normal T-lymphocytes) expresses uniformly CD3 and/or CD5; (2) more than 80% of total lymphoid cells have a homogeneous expression of CD4 or CD8; or (3) any aberrant phenotype in CD3 or CD5 positive cells is present, including the loss of membrane expression of CD3 in cells retaining cytoplasmic expression of CD3 only. Here, CD8A is linked to lymphoma.