Previous observations documented that CD11b/CD18, a surface receptor expressed in cellular inflammatory responses by neutrophils and activated monocytes macrophages (8, 9), can promote their adhesion to endothelial lining and binding soluble clotting factor X and that fibrinogen acts as a trigger of coagulation cascade and thrombosis, similar to what is reported in ischemic diseases. Here, ITGB2 is linked to ischemic disease.