LDLR and atherosclerosis: Furtherly, the research of Malhotra et al. shows EndMT and vascular calcification in vitro and in vivo are dependent upon BMP signaling in MGP-deficient mice, while the other hand, also suggests that activation of BMP signaling inhibits atherosclerosis in MGP-deficient mice fed a standard diet when compared to LDLR–/– mice fed a high fat diet, a murine model of atherosclerosis (73).