CLPB and leptospirosis: In the case of L. interrogans, the causative agent of the emerging zoonotic disease leptospirosis, a clpB mutant not only showed enhanced susceptibility to high temperature, nutrient-depletion, and oxidative stress, but was also attenuated in a gerbil animal model of acute leptospirosis (Lourdault et al., 2011; Kêdzierska-Mieszkowska and Arent, 2020).