PTGS1 and asthma: Our results suggested that the core potential targets of MGMD were intensively enriched in the pathways related to SPMs biosynthesis, including ALOX5 (5-LOX), ALOX15 (15-LOX), PTGS1 (COX1), PTGS2 (COX2), cytochrome P450 proteins CYP2C9 and CYP2C19, which paly pivotal role in the resolution of inflammation in asthma (Schett and Neurath, 2018; Kytikova et al., 2019).