For example, in the Combination Therapy with Adalimumab in Subjects with Early Rheumatoid Arthritis (CONCERTO) study, high-dose (i.e., 20 mg/week) MTX administered in a regimen with the TNF inhibitor adalimumab (ADA) resulted in a three-fold higher remission rate than low-dose (2.5 mg/week) MTX with ADA in bio-naive patients with early-stage RA (4). This evidence concerns the gene TNF and rheumatoid arthritis.