SMARCB1 and Coffin-Siris syndrome: More than 80% of Coffin-Siris syndrome cases are caused by mutations in one of the following genes: Arid1A, Arid1B, Brg1, Brm, Snf5/Ini1, or BAF57, which encode the subunits of the BRG1-associated factors (BAF) chromatin-remodeling complex (vertebrate homolog of the SWI/SNF complex; Schrier et al., 2012; Kosho et al., 2013, 2014).