COP1 and Miyoshi myopathy: As expected, Kaplan-Meier survival curves showed that MM patients with amplification of RFWD2 were significantly associated with poor overall survival (OS) in 3 independent MM cohorts (TT3, APEX and HOVON65) [Figures 1A,B (A-right)], which were in sync with the results of TT2 (a well-annotated, mature data set) and GMMG-HD4 cohort (Gu et al., 2020).