PML NBs are dynamic structures harboring a few permanent resident proteins (e.g., PML, Sp100, and SUMO) and numerous transient proteins depending on cell stimulation (i.e., stress, IFN, or viral infection) (van Damme et al., 2010; Geoffroy and Chelbi-Alix, 2011). The gene discussed is IFNA1; the disease is viral infectious disease.