PML NBs are implicated in various processus including stress response, apoptosis, protein degradation, viral infection and IFN response (Regad and Chelbi-Alix, 2001; Everett and Chelbi-Alix, 2007; Bernardi et al., 2008; Geoffroy and Chelbi-Alix, 2011; Nisole et al., 2013). The gene discussed is IFNA1; the disease is viral infectious disease.