It is well established that several infections with DNA and RNA viruses result in PML degradation and/or PML NB disorganization (Everett and Maul, 1994; Chelbi-Alix and de The, 1999; Muller and Dejean, 1999; Everett and Chelbi-Alix, 2007; Tavalai and Stamminger, 2008; El McHichi et al., 2010; Geoffroy and Chelbi-Alix, 2011), suggesting that PML NB alteration could be a viral strategy to evade cellular resistance mechanisms. This evidence concerns the gene PML and infection.