ENO1 and cancer: ENO1 is a glycolysis-associated enzyme that participates in various cancers (Nakajima et al., 1986; Tu et al., 2010; Song et al., 2014; Fu et al., 2015; Liu et al., 2015; Principe et al., 2015; Zhu et al., 2015, 2018; Niccolai et al., 2016; Qian et al., 2017; Zhan et al., 2017); therefore, we focused on glycolysis-associated pathways; the mTOR/HIF1α pathway is also involved in glycolysis (Majumder et al., 2004; Semenza, 2011; Chi, 2012; Cheng et al., 2014; Courtnay et al., 2015; Yang et al., 2015; Xiao et al., 2017).