ENO1 and cancer: ENO1 plays critical and multifunctional roles in various physiological and pathological processes (Pancholi, 2001; Ejeskar et al., 2005; Diaz-Ramos et al., 2012; Principe et al., 2015; Capello et al., 2016), including tumorigenesis, cancer invasion, and metastasis (Hsiao et al., 2013; Song et al., 2014).