Ectopic ENO1 overexpression promoted tumor formation and tumor chemoresistance (Tu et al., 2010; Song et al., 2014; Fu et al., 2015; Principe et al., 2017; Qian et al., 2017; Zhan et al., 2017; Sun et al., 2019; Chen et al., 2020). Here, ENO1 is linked to neoplasm.