The underlying molecular mechanism might be related to hypoxia, which induces different regulation patterns in many cell cycle checkpoint genes such as HIF-1a, ataxia telangiectasia mutated, and ataxia telangiectasia and Rad3 related p53, p21, p27, and p21 (Sharma and Bhonde, 2015). This evidence concerns the gene HIF1A and telangiectasis.