For instance, it has been proven that high levels of IL-6, a major immunoregulatory cytokine, are associated with TME alterations by binding to its specific receptor IL-6R, whose increased expression, as well as its soluble spliced variant, is regulated by tumor-associated inflammation, leading to death (Rath et al., 2010; Lane et al., 2011). This evidence concerns the gene IL6 and neoplasm.