GLI1 and glioblastoma: Moreover, Hedgehog signaling transcription factor Gli1/Gli2 appears to be the primary regulator of drug response in hepatoma, Oral squamous cell carcinoma (OSCC) and Colorectal cancer (CRC) through the ABC transporter and in Acute Myleiod Leukemia and GBM through MRP1 (Shahi et al., 2016; Ding et al., 2017; Huang K. et al., 2019; Lu et al., 2020; Po et al., 2020).