VEGFA and myocardial infarction: The delivery of VEGF gene using direct injection of naked plasmids or adeno-associated viruses (AAVs) has produced positive results in the activation of angiogenic genes and vascular regeneration, in critical limb ischemia and myocardial infarction models (Schwarz et al., 2000; Boden et al., 2016; Liu et al., 2017; Samatoshenkov et al., 2020).