DNAH8 and amyotrophic lateral sclerosis: By downregulating ATP1F1, pre-miR-146a may also ameliorate mitochondrial respiratory chain dysfunction because it inhibits ATPase activity (Chen et al., 2014), contributing to sustain ALS MN mitochondrial functionality (Li et al., 2010; Chen et al., 2014), and thus preventing the apoptosis induced by the secretome from pre-miR-146a-treated mSOD1 astrocytes.