Besides, genetic upregulation of miR-146a restored the protein levels of S100B (Figures 2J,L, p < 0.001) and of Cx43 (Figures 2J,M, p < 0.01) toward the control values, attesting that the reduction of miR-146a expression may contribute to the cortical astrocyte aberrancies associated to the ALS disease and to MN degeneration. The gene discussed is GJA1; the disease is amyotrophic lateral sclerosis.