In what concerns the immunoglobulin superfamily DCC subclass member 4, encoded by Igdcc4 and accepted as a biomarker of hepatocellular carcinoma (Zweerink et al., 2020) and of innate immune/inflammatory response (Sanz-Pamplona et al., 2014), it should be explored in the future as part of the recovering microglia steady-state profile by pre-miR-146a in ALS cortical astrocytes through paracrine signaling. Here, IGDCC4 is linked to amyotrophic lateral sclerosis.