DLAT and amyotrophic lateral sclerosis: Motor neuron proteomic analysis revealed that pre-miR-146a increases the E2 component of the pyruvate dehydrogenase complex encoded by the Dlat gene (Goguet-Rubio et al., 2016), leading to the production of ATP that is required to continuously provide energy to maintain normal MN function with a high relevance in ALS (Vandoorne et al., 2018).