PLAT and von Willebrand disease (hereditary or acquired): Generic Indications•For bleeding with fibrinogen <100 mg/dL •For massive hemorrhage with fibrinogen <150–200 mg/dL •For acute phase of APML with fibrinogen <150 mg/dL •ICH secondary to treatment with tPA with fibrinogen <200 mg/dL •Treatment of bleeding in patients with vWD or Hemophilia A, only when:  Factor concentrates are unavailable, remote geographic region and DDAVP is unavailable or ineffective