Our study failed to show any correlation of the presence of these mutations with age, gender, smoking, stage, or grade of the tumor, which is consistent with the prospective clinical study of EGFR mutations by Smilek et al.10The Smilek study comprised 29 cases of HNSCC and detected two cases (stage III and IV) with the EGFR mutation. The gene discussed is EGFR; the disease is neoplasm.