CYBB and infection: However, the ROS produced by NOX2 can also be secreted outside phagosomes to cause an oxidative stress of C. albicans prior to phagocytosis (Frohner et al., 2009; Miramon et al., 2012), which will recruit more phagocytes to the infection site (Brothers et al., 2013), limit filamentous growth intracellularly (Brothers et al., 2013) and form new toxic substances with other chemicals (Brown et al., 2009), eventually forming a fungicidal environment for C. albicans (Dantas Ada et al., 2015).