Recently, two main molecular subtypes of LCNEC have been identified by next generation sequencing (NGS) studies, namely type I with TP53 and STK11/KEAP1 alterations (NSCLC type), and type II with TP53 and RB1 alterations (SCLC type) (8). The gene discussed is KEAP1; the disease is large cell neuroendocrine carcinoma.