Additionally, less common molecular alterations seen almost exclusively in the NSCL-like LCNEC involved the BRAF, MAP2K1, ERBB2, and CDKN2A genes, and those seen exclusively in the SCLC-like LCNEC included MYCL1 amplification and PTEN mutations. The gene discussed is PTEN; the disease is large cell neuroendocrine carcinoma.