reported the existence of two LCNEC genomic subtypes with specific transcriptional patterns, which they categorized as type I (NSCLC type) with TP53 and STK11/KEAP1 alterations and type II (SCLC type) with TP53 and RB1 alterations, which is introduced in the upcoming 2021 WHO classification (8). Here, TP53 is linked to non-small cell lung carcinoma.