Generation of SEMMs via transformed Trp53 null adult neural stem cells implanted into immunodeficient NCr-Foxn1nu mice helped characterize four potential gene-fusion drivers: Fgfr3-Tacc3, Sec61g-Egfr, Bcan-Ntrk1 and Gga2-Prkcb, but only cells harboring the fusion BCAN-NTRK1 generated high-grade gliomas (18). Here, BCAN is linked to glioma.