A more consistent experimental outcome was obtained when heterozygous LSL-KrasG12D mice were infected with lentivirus containing expression vectors for Cas9, Cre, and a sgRNA targeting Trp53. The resulting adenocarcinomas were consistent with NSCLC features demonstrated by Cre-activated lung tumors of KrasLSLG12D/WTxTrp53flox/flox established tumor models (15). Here, TP53 is linked to neoplasm.