Finally, a major study by Dammeijer et al. suggested that, while PD-1/PD-L1 blockade therapy is generally thought to reinvigorate progenitor-exhausted T cells and to relieve tumor T-cell-mediated suppression in the TME, tumor-draining lymph nodes are a major component of anti-PD-1/PD-L1-mediated tumor immunity. This evidence concerns the gene CD274 and neoplasm.