Following this immunogenic cell death, DCs then migrate to the tumor-draining lymph nodes and prime CD8+ T cells (7), with in turn leukocyte extravasation and recruitment to the tumor site through chemokine secretion by tumor cells and other cell types in the tumor micro-environment (CXC motif chemokine ligand (CXCL)9, CXCL10, and CXCL16) (8, 9). The gene discussed is CXCL16; the disease is neoplasm.