CGAS and neoplasm: During phagocytosis by myeloid cells, DNA fragments hidden in irradiated tumor cells are released from tumor-derived exosomes to the cytoplasm of myeloid cells (37), and cytosolic DNA stimulates the secretion of IFN-β through the activation of the DNA sensor cGAS and its downstream effector STING, in turn promoting the cross-priming of CD8+ T cells (5).