Recently, Liu et al. used a combination of HDFI (8 Gy x 3) with low-dose total body irradiation (0.1 Gy) in syngeneic mouse models of breast and colon carcinoma and found an enhanced systemic anti-tumor response as compared to HDFI alone, by infiltration of CD8+ T cells dependent on IFN-γ and alteration of the immunosuppressive TME of secondary tumors (89). This evidence concerns the gene CD8A and neoplasm.