CDH1 and breast cancer: Genes with low penetrance such as androgen receptor (AR), checkpoint kinase 2 (CHEK2), E-cadherin, Nijmegen breakage syndrome 1 (NBS1), RAD50, BRCA1 interacting protein C-terminal helicase 1 (BRIP1), and partner and localizer of BRCA2 (PALB2) are frequently mutated in the general population and play an important roles in the occurrence of breast cancer (11).