KDR and bone metastasis: Exploratory analyses of PFS and OS in the intent-to-treat population also showed consistent results in favor of cabozantinib compared to everolimus in different subgroups defined by age (<65 years compared to ≥65 years), sex, risk group, ECOG status (0 compared to 1), time from diagnosis to randomisation (<1 year compared to ≥1 year), tumor expression of MET (high compared to low compared to unknown), bone metastasis, visceral metastasis, number of VEGFR-TKIs previously received (one vs two), and duration of first treatment with VEGFR-TKI (≤6 months vs >6 months).