FLT3 and cancer: Cabozantinib is a multi-targeting TKI directed against the receptors of factors involved in tumor growth, angiogenesis, pathological bone remodeling, chemoresistance, and metastatic progression of cancer, such as VEGF, MET, GAS6(AXL), RET, ROS1, TYRO3, MER, KIT (stem cell factor), TRKB, Fms-like tyrosine kinase-3 (FLT3), and TIE-2 (32).