Furthermore, when evaluating PKH signal with pro-tumor M2 like macrophage markers, tumor cell-derived PKH26 was found within a higher proportion of M2 like macrophages when compared to fibroblast-derived PKH67 (Figure 5F); this is further demonstrated by ImageStream flow cytometry, where punctate PKH26+ regions are observed within CD64+ macrophages but few PKH67+ regions are observed (representative image-stream strips, Figure 5G). The gene discussed is PDXK; the disease is neoplasm.