DP CD8 T cells did not significantly share TCR sequences with CD8 T cells in the tumor draining lymph node or the peripheral blood, while CD103-CD39- (double negative – DN) CD8 T cells did share TCR sequences with circulating cells (38), suggesting that the DP CD8 T cells are selectively retained within the tumor and the DN CD8 T cells are recirculating. The gene discussed is ITGAE; the disease is neoplasm.