APC and esophageal adenocarcinoma: Surprisingly, hypermethylation in the APC promoter was detected both in tissue from esophagus adenocarcinoma and squamous cell carcinoma without any radiotherapy or chemotherapy, which occurred in esophageal tissues in 68–92% of patients with esophageal adenocarcinoma, in 44–50% of patients with esophageal squamous cell carcinoma, but not in matching normal esophageal tissues (39, 42–44), as shown specifically in Table 1.