CD177 and breast cancer: Integrins belong to the transmembrane protein family and act as cell surface receptors that mediate cell-to-cell and cell-to-matrix adhesion by identifying components of ECM, such as FN, laminin, collagen, and transmit information from ECM to cells (118), leading to the recruitment and activation of intracellular signaling proteins, which in turn initiates a signaling cascade that promotes breast cancer cell migration, proliferation, and survival (119, 120).