They proposed that endostatin may inhibit mouse BC growth in vivo by regulating the polarization of tumor-associated macrophages via two possible mechanisms: by shifting the polarity of the tumor-associated macrophage from an M2-like to an M1-like functional phenotype or by increasing the proportion of M1-like tumor-associated macrophage via specific inhibition of M2 polarity (99). The gene discussed is COL18A1; the disease is neoplasm.