VWF and lung carcinoma: Liu group found that VWF expression in endothelial cells of LUAD is elevated by the cancer cell-derived secretome through GATA3-mediated transcription (45); According to a study, which digs out the association between VWF and its cleaving protease (ADAMTS-13) in lung cancer metastasis, the elevation of VWF/ADAMTS-13 ratio may serve as an independent predictive factor for mortality in patients with advanced NSCLC (46).