Based on differential HCST expression, CIBERSORT analysis was used to evaluate the estimated proportions of tumor-infiltrating immune cells in ccRCC, which included naïve B cells, activated DCs, eosinophils, M2 macrophages, resting mast cells, monocytes, neutrophils, resting NK cells, plasma cells, activated CD4 memory T cells, resting CD4 memory T cells, CD8 T cells, follicular helper T cells, gamma delta T cells, and regulatory T cells. Here, CD8A is linked to nonpapillary renal cell carcinoma.