As shown in Table 2, Cox univariate survival analysis indicated that grade (p < 0.001), TNM stage (p < 0.001), lymph node metastasis (p = 0.001), invasion depth (p < 0.001), distant metastasis (p < 0.001), and HCST expression (p = 0.005) were important parameters affecting the duration of OS, while multivariate Cox survival analysis showed that grade, distant metastasis, and HCST expression were independent factors of a poor prognosis of ccRCC patients (all, p < 0.05) (Figure 6). This evidence concerns the gene HCST and nonpapillary renal cell carcinoma.