LV-MLK7-AS1 and sh-MLK7-AS1 were transfected in NSCLC cells to explore the relationship between MLK7-AS1 and miR-375-3p, which revealed that LV-MLK7-AS1 downregulated the miR-375-3p expression, whereas sh-MLK7-AS1 upregulated the miR-375-3p expression in H1299 and A549 cells (Figures 2D, E). The gene discussed is PTGDR; the disease is non-small cell lung carcinoma.