Bocci et al. observed through a mechanism-based dynamical model that the diffusion of EMT-inducing signals such as TGF-β, together with non-cell autonomous control of EMT and CSC decision-making via the Notch signaling pathway, can explain the experimentally observed disparate localization of subsets of CSCs with varying EMT phenotypes in the tumor (74). This evidence concerns the gene TGFB1 and neoplasm.