MAPK1 and neoplasm: The positive expression rate of p-p38 in tumor tissues from group A (125I seed treatment) was significantly higher than group B (control) and group C (non-activity 125I seed) [85.7% (12/14) compared with 28.5% (4/14) and 35.7% (5/14), respectively] (P <0.05, group A vs. B) (Figure 5A).