IL6 and colorectal carcinoma: Elevated IL-6 produced from the cancer microenvironment could effectively inhibit the synthesis of Alb and pre-Alb (40), whereas IL-17 facilitated cisplatin resistance in CRC by inhibiting cancer cell apoptosis through targeting p-Akt, Bax, Bcl-2, and mTOR (41), promoting its pro-proliferative and antiapoptotic properties (42).