Our previous study showed that circulating Fib-to-pre-Alb ratio (FPR) could sensitively imply the body response to chronic inflammation in solid malignancies (21), including hepatocellular carcinoma (22), and gastric cancer (23) as well as CRC (24), and it was superior to other inflammatory ratios or scores to predict the survival of CRC patients (25). This evidence concerns the gene FBL and colorectal carcinoma.