The screening panel of CD is usually based on serological testing especially tissue transglutaminase antibody (tTG IgA) (with high sensitivity and specificity) and anti-endomysial antibody (EMA) (to confirm the tTG IgA result), and the definitive diagnosis is made by pathological findings on the small bowel biopsy [2]. This evidence concerns the gene TGM2 and Cowden disease.