AIFM1 and ovarian cancer: These results are consistent with previous studies conducted by [17], showing that cisplatin exposure induces a mitochondrial-dependent ROS response that significantly contributes to cell killing by enhancing the cytotoxic effect exerted through the formation of nDNA damage [15], which states that translocation of the AIF protein from mitochondria can be induced by cisplatin in chemosensitive ovarian cancer cells and causes apoptosis.