MTA2 and cancer: To get heterogeneous CBPs (Supplementary Table 1), directed regulatory pathways containing miRNAs and genes, which correspond to each cancer subtype we put subtype-specific multi-omics modules obtained from matrix U(p), p = 1, 2 onto an integrated gene regulation network from Reactome (Croft et al., 2014), Kyoto Encyclopedia of Genes and Genomes (KEGG) (Kanehisa and Goto, 2000), and Nci-PID pathway (Schaefer et al., 2009).