KRAS and cancer: For the choice of the regulatory elements, we focused on the signature genes of the MAP-kinase pathway (KRAS, BRAF), frequently mutated kinases/TFs (TP53, ARID1A, CDH1, and ERBB2) (Gastric Adenocarcinoma - My Cancer Genome) and significantly upregulated TFs (log2FC > 0.5, BH-adjusted P < 0.01) as well as downregulated miRNAs (log2FC < −1, BH-adjusted P < 0.01) in the EMT subtype.