CASP1 and nephrocalcinosis: To address the potential contribution of caspase 1 and NADPH oxidase 2 ﻿during nephrocalcinosis, we fed 129/B6J mice deficient in Casp1, Cybb and Casp1/Cybb an oxalate-rich diet, a previously characterized mouse model of CaOx crystal-induced nephropathy (31).