For example, mutations in genes controlling IL-17 signaling (ACT1, IL17RA, IL17F), genes that drive Th17 development (DECTIN1, CARD9, STAT3, STAT1, IL12RB) or in individuals with naturally-occurring anti-IL-17 Abs (AIRE deficiency) showed increased susceptibility to mucosal Candidiasis, but not invasive Candidiasis (79). The gene discussed is AIRE; the disease is candidiasis.