In our patient, a distinct population of LAMP3+ dendritic cells expressed the CTLA4 receptors CD80 and CD86, as well as IDO1. They also expressed TNFRSF14 and PVR, the receptors for TNFSF14 (LIGHT) and TIGIT, respectively, which are both synthesized by the tumor cells, and might additionally enhance local Th2 immune skewing (31, 64). Here, TIGIT is linked to neoplasm.