The finding of autoantibody against NMDAR in the central nervous system demyelinating diseases is limited to a few case reports, such as myelin oligodendrocyte glycoprotein (MOG) inflammatory demyelinating diseases (5), neuromyelitis optica spectrum disorders (NMOSDs) (6), and acute disseminated encephalomyelitis (ADEM) (7), and the association between anti-NMDAR antibody and MS is even more rare (8). The gene discussed is MOG; the disease is acute disseminated encephalomyelitis.